CRISPR/Cas9 | KAIST MatriX

Tag: CRISPR/Cas9

Research Highlight

Machine Learning Uncovers Transcriptional Regulatory Networks of the Human Gut Symbiont Bacteroides thetaiotaomicrons

Independent component analysis of 461 RNA-seq datasets reveals 110 transcriptional regulatory modules (iModulons) in Bacteroides thetaiotaomicron, expanding its known regulatory network by 22.4% and characterizing 11 previously unknown ECF-sigma factors. ...read more

Bacteroides thetaiotaomicron CRISPR/Cas9 ECF sigma factor Gut microbiome Machine Learning RNA-seq Transcriptional regulatory network

Research Highlight

CRISPR-Based UPR Reporter Reveals Mechanism of Antibody Homeostasis in Hybridomas

CRISPR editing and proteomics reveal UPR-mediated control of antibody homeostasis and enable a BiP-based reporter to monitor antibody production stability....read more

Antibody production CRISPR/Cas9 ER stress Hybridoma Immunoglobulin Proteomics UPR

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