A Neuromodulation System with Real-Time Neural Signals Recovery Overlapped Temporally and Spectrally with Stimulation Artifacts
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A Neuromodulation System with Real-Time Neural Signals Recovery Overlapped Temporally and Spectrally with Stimulation Artifacts

Professor Chul Kim’s group at KAIST has developed a neuromodulation system that recovers neural signals in real time even when electrical stimulation artifacts overlap with them in both time and frequency. The system removes artifacts directly on a compact chip without prior calibration, supporting continuous monitoring during stimulation. The study was published online on January 20, 2026, in IEEE Transactions on Biomedical Circuits and Systems. Addressing signal loss during stimulation Electrical stimulation produces artifacts that are much larger than the neural signals researchers wish to observe. Discarding contaminated recording periods also removes neural information, while conventional frequency filtering cannot readily separate signals and artifacts that share the same frequencies. These limitations make it difficult to monitor neural activity continuously and use it to guide stimulation. Adaptive recovery directly on the chip The team developed an adaptive algorithm that estimates the artifact waveform and subtracts it from incoming recordings. ...read more