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Research Highlight
In Situ Tumor-Infiltrating Lymphocyte Therapy by Local Delivery of an mRNA Encoding Membrane-Anchored Anti-CD3 Single-Chain Variable Fragment
Prof. Park’s group developed mRNA-LNPs to engineer macrophages and cancer cells in solid tumors for in situ TIL therapy, demonstrating significant antitumor effects. ...read more
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Research Highlight
New Nanoparticle Drug Combination Treats and Prevents Atherosclerosis
Dr. Ji-Ho Park’s group developed a cargo-switching nanoparticle (CSNP) system that can bind to cholesterol and then release an anti-inflammatory drug (statin) in a plaque-containing microenvironment. The as-developed CSNP had a core-shell structure, with a core composed of cyclodextrin and statin and a shell of phospholipids. In vitro, once interacting with cholesterol, which had a higher affinity to cyclodextrin than statin, the CSNP can instantly release statin and scavenge cholesterol by cargo-switching. In vivo, in a mouse model of atherosclerosis, the CSNP administered systemically can effectively target atherosclerotic plaques and reduce their associated cholesterol and macrophages, leading to prevention of atherogenesis and regression of established plaques....read more
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Research Highlight
Microfluidic Smart Blood Typing by Finger Actuation
A microfluidic smart blood-typing device operated by finger actuation is reported. The blood-typing results are displayed by means of microfluidic channels with the letter and the symbol of the corresponding blood type. To facilitate the mixing of blood and reagents in the device, the two sample inlets are connected to a single actuation chamber. According to the agglutination aspect in the mixture, the fluids are directed to both microslit filter channels and bypass channels, or only to bypass channels. With this device, blood typing was successfully performed by seven button pushes, using less than 10 μL of blood within 30 s....read more
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