Ciliopathies are clinically overlapping genetic disorders involving structural and functional abnormalities of the cilia. CEP290, a gene mutated in several ciliopathies, encodes a protein that forms a complex with NPHP5 to support the function of the ciliary transition zone. In this study, the CRISPR/Cas9 system was used to generate a cell line model for CEP290-related ciliopathy, and cell-based chemical library screening identified eupatilin as a lead compound for developing ciliopathy medication. Eupatilin relieved ciliogenesis defects resulting from inactivation of the CEP290 gene. In rd16 mice harboring a blinding Cep290 in-frame deletion, eupatilin treatment improved both opsin transport to the photoreceptor outer segment and electrophysiological responses of the retina to light stimulation. The rescue effect was due to eupatilin-mediated inhibition of calmodulin binding to NPHP5, which promoted NPHP5 recruitment to the ciliary base. These results demonstrate that eupatilin rescues ciliary transition zone defects to ameliorate ciliopathy-related phenotypes....read more
At KAIST Institute for IT Convergence, professor Sung-Kwan Jung’s research team developed a LoRa based low-power wireless monitoring system for industrial battery diagnosis. They ultimately developed industrial wireless gateways with the IoT Edge Platform, two types of low-power wireless sensors, and LoRa modules for low-power wireless communications. They are now testing the results on a real industrial site....read more
Many techniques are being developed to facilitate the diagnosis of an individual's illness using a portable point of care testing machine. A system has been developed to operate a single photon-capable SiPM (Silicon Photomultiplier) by amplifying low-intensity light by 1 million times through internal amplification. Using this technology it will be possible to easily diagnose diseases and illnesses such as diabetes, nephrotic syndrome, glomerulonephritis, and infection from urine samples at an early stage....read more
Through years of collaboration with NAVER LABS, Prof. Ayoung Kim’s team introduced their dataset toward 3D urban mapping for the robotics community. The dataset paper was also accepted and will be presented in May at a major robotics conference, International Conference on Robotics and Automation (ICRA)....read more
Professor Doh Chang Lee’s team unveiled the growth mechanism of colloidal semiconductor nanorods (NRs). Atomic-precision control of NR morphologies and structures achieved in the teams’ work is expected to make a shattering impact on a wide range of nanomaterials, particularly in display applications....read more
KAIST systems metabolic engineers defined a novel strategy for microbial aromatic polyesters production fused with synthetic biology from renewable biomass....read more
A novel method can improve T1 MR image compatibility across different centers to study Alzheimer's disease ...read more
The human emotion monitoring skin patches monitor multiple physiological skin symptoms to determine human emotion, including stress, emotional touch, and thermal status. ...read more
Well-defined colloidal zinc oxide-copper(I) oxide hybrid nanocatalysts behaved as photocatalysts for the direct conversion of carbon dioxide to methane in an aqueous medium under ambient pressure and room temperature. The activity was 1080 mmolgcat-1h-1 with a quantum yield of 1.5%, which were two magnitudes superior to any other catalysts under aqueous environments. Moreover, the selectivity to methane approached 100%, meaning that carbon dioxide could be exclusively converted into pure fuels by sunlight....read more
New simulation techniques based on big data obtained from molecular simulations can indirectly help model degraded porous materials. As such, the new method can be used to understand properties of materials in the absence of structural information....read more