Research Highlight

Systems-level Analyses of Streptomyces Genome Identify Genes for Novel Antibiotics Production

The growing number of antibiotic-resistant bacteria is a substantial global public health concern. Traditional antimicrobial and antibiotic development strategies are no longer effective against the quickly rising resistance to virtually all drugs on the market, and to date there are only a few approved efficient vaccines against the potentially fatal superbacterial infections. To counteract this threat, the genetic potential of Streptomyces species has been explored to produce a diverse array of new antibiotics. Here we show systems-level analyses of multiple genome-wide data sets elucidating the relationship between transcription and translation of the antibiotic-producing bacterium, Streptomyces coelicolor. Our findings offer target genes for a potentially novel route for strain engineering to enhance novel antibiotics production....read more