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Research Highlight
Optogenetic Control of mRNA Localization and Translation in Live Cells
A new optogenetic approach called mRNA-LARIAT enables the direct optogenetic control of localization and translation of specific mRNAs in living cells....read more
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Research Highlight
A Novel Mechanism of Nucleosome Recognition and Destabilization by Leukemia Related Protein
Ji-Joon Song’s research team revealed the working mechanism of DOT1L-Leukemia Related Protein, which recognize the histone code and destabilizes nucleosome....read more
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Research Highlight
A Peptide-Antibody Hybrid Platform for Targeted Cancer Therapy
Synergy in hybrid-A new hybrid platform is developed based on a hapten-labeled bispecific peptide and an anti-hapten antibody to overcome the short plasma half-life of most peptide therapeutics....read more
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Research Highlight
Noninvasive Optical Activation of Flp Recombinase in Deep Mouse Brain Regions
Spatiotemporal control of gene expression or labeling is a valuable strategy for identifying functions of genes within complex neural circuits. Here, we develop a highly light-sensitive and efficient photoactivatable Flp recombinase (PA-Flp) that is suitable for genetic manipulation in vivo. The highly light-sensitive property of PA-Flp is ideal for activation in deep mouse brain regions by illumination with a noninvasive light-emitting diode. In addition, PA-Flp can be extended to the Cre-lox system through a viral vector as an Flp-dependent Cre expression platform, thereby activating both Flp and Cre....read more
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