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Research Highlight
Glycocalyx-mimicking nanoparticles for organ-selective drug delivery and therapy
Professor Sangyong Jon’s group has developed an organ-selective drug delivery platform based on a library of glycocalyx-mimicking nanoparticles (GlyNPs). Direct in vivo library screening enables identification of GlyNP hits targeting the liver, spleen, lung, kidneys, heart, and brain. When liver-, kidney-, and spleen-selective GlyNP hits are equipped with therapeutics, the formulations effectively alleviated symptoms in organ-associated disease models....read more
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Research Highlight
A Peptide-Antibody Hybrid Platform for Targeted Cancer Therapy
Synergy in hybrid-A new hybrid platform is developed based on a hapten-labeled bispecific peptide and an anti-hapten antibody to overcome the short plasma half-life of most peptide therapeutics....read more
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Research Highlight
Decorating Tumor Cell Membranes with Synthetic Receptors to Improve Targeted Cancer Therapy
Delivery of synthetic receptors to tumor cell membranes using both synthetic and biological nanoparticles led to effective treatment of cancer....read more
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