-
Research Highlight Top Story
Computational design of a neutralizing antibody against all SARS-CoV-2 variants
Prof. Oh’s group has developed a neutralizing antibody against SARS-CoV-2 by computational method. The antibody binds to all SARS-CoV-2 variants, including Omicron, with pico- to femto-molar binding affinity....read more
-
Research Highlight
A Peptide-Antibody Hybrid Platform for Targeted Cancer Therapy
Synergy in hybrid-A new hybrid platform is developed based on a hapten-labeled bispecific peptide and an anti-hapten antibody to overcome the short plasma half-life of most peptide therapeutics....read more
-
Research Highlight
Noninvasive Optical Activation of Flp Recombinase in Deep Mouse Brain Regions
Spatiotemporal control of gene expression or labeling is a valuable strategy for identifying functions of genes within complex neural circuits. Here, we develop a highly light-sensitive and efficient photoactivatable Flp recombinase (PA-Flp) that is suitable for genetic manipulation in vivo. The highly light-sensitive property of PA-Flp is ideal for activation in deep mouse brain regions by illumination with a noninvasive light-emitting diode. In addition, PA-Flp can be extended to the Cre-lox system through a viral vector as an Flp-dependent Cre expression platform, thereby activating both Flp and Cre....read more
291 Daehak-ro Yuseong-gu Daejeon, 34141, Republic of Korea
Partnered with KAIST Breakthroughs and KAIST Compass