Research Highlight

Sex-specific effects of social isolation on shaping social behavior and maturing cortical neurons during adolescence

Prof. Lee’s group found adolescent social isolation dampens sociability and cortical maturation only in female mice. They performed anatomical, physiological, behavioral, genetic knock-out, and optogenetic studies to prove that the expression of a specific gene, parvalbumin, in GABAergic neurons is important for shaping sociability in female mice....read more