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Research Highlight
Engineering Bacteria to Produce Methyl-Anthranilate, a Grape Flavoring Compound
A direct fermentative approach to renewable methyl anthranilate (MANT) production from glucose is possible with metabolically engineered Escherichia coli and Corynebacterium glutamicum strains harboring a synthetic plant-originating metabolic pathway. This bio-based production platform will allow MANT, an important and widely used compound to impart grape scent and flavor, to be produced in a completely natural and sustainable manner....read more
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Research Highlight
Systems-level Analyses of Streptomyces Genome Identify Genes for Novel Antibiotics Production
The growing number of antibiotic-resistant bacteria is a substantial global public health concern. Traditional antimicrobial and antibiotic development strategies are no longer effective against the quickly rising resistance to virtually all drugs on the market, and to date there are only a few approved efficient vaccines against the potentially fatal superbacterial infections. To counteract this threat, the genetic potential of Streptomyces species has been explored to produce a diverse array of new antibiotics. Here we show systems-level analyses of multiple genome-wide data sets elucidating the relationship between transcription and translation of the antibiotic-producing bacterium, Streptomyces coelicolor. Our findings offer target genes for a potentially novel route for strain engineering to enhance novel antibiotics production....read more
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